Response to “Use of Oral Furosemide in Hemodialysis”

We thank Siga and Alcuaz for their interest in our study that examines the efficacy, safety, and tolerability of oral furosemide among individuals treated with maintenance hemodialysis.1,2 The authors share their experience in Argentina of administering oral furosemide at doses of 500 mg/d to incident hemodialysis patients with daily urine output of >200 ml. They observed maintenance of urine output with minimal side effects after nearly a year of follow-up under this regimen. Their preliminary report, in combination with our data, support the need for larger trials testing the effectiveness of furosemide for improving volume-related outcomes among patients treated with hemodialysis.