Lynch syndrome‐related colorectal carcinomas are NTRK‐negative

HistopathologyEarly View Correspondence Lynch syndrome-related colorectal carcinomas are NTRK-negative Andrea Remo, Corresponding Author Andrea Remo [email protected] Department of Pathology, “Mater Salutis” Hospital, Verona (VR), ItalyAddress for correspondence: Andrea Remo, Department of Service, Pathology Unit, ULSS9 “Scaligera”, Verona 37132, Italy. e-mail: [email protected]Search for more papers by this authorFederica Grillo, Federica Grillo orcid.org/0000-0001-6477-3182 Department of Surgical and Diagnostic Sciences (DISC), University of Genoa and S. Martino Polyclinic Hospital, Genoa (GE), ItalySearch for more papers by this authorAlessandro Vanoli, Alessandro Vanoli orcid.org/0000-0002-2976-7032 Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, ItalySearch for more papers by this authorPaola Parente, Paola Parente orcid.org/0000-0003-0591-6723 Unit of Pathology, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, ItalySearch for more papers by this authorLuca Mastracci, Luca Mastracci orcid.org/0000-0003-0193-5281 Department of Surgical and Diagnostic Sciences (DISC), University of Genoa and S. Martino Polyclinic Hospital, Genoa (GE), ItalySearch for more papers by this authorValentina Angerilli, Valentina Angerilli Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua (PD), ItalySearch for more papers by this authorEmanuele Damiano Urso, Emanuele Damiano Urso Chirurgia Generale 3^, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, ItalySearch for more papers by this authorFrancesca Bergamo, Francesca Bergamo Medical Oncology Unit 1, Clinical and Experimental Oncology Department, Veneto Institute of Oncology, IOV-IRCCS, Padua (PD), ItalySearch for more papers by this authorMatteo Fassan, Matteo Fassan Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua (PD), Italy Veneto Institute of Oncology, IOV-IRCCS, Padua (PD), ItalySearch for more papers by this author Andrea Remo, Corresponding Author Andrea Remo [email protected] Department of Pathology, “Mater Salutis” Hospital, Verona (VR), ItalyAddress for correspondence: Andrea Remo, Department of Service, Pathology Unit, ULSS9 “Scaligera”, Verona 37132, Italy. e-mail: [email protected]Search for more papers by this authorFederica Grillo, Federica Grillo orcid.org/0000-0001-6477-3182 Department of Surgical and Diagnostic Sciences (DISC), University of Genoa and S. Martino Polyclinic Hospital, Genoa (GE), ItalySearch for more papers by this authorAlessandro Vanoli, Alessandro Vanoli orcid.org/0000-0002-2976-7032 Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, ItalySearch for more papers by this authorPaola Parente, Paola Parente orcid.org/0000-0003-0591-6723 Unit of Pathology, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, ItalySearch for more papers by this authorLuca Mastracci, Luca Mastracci orcid.org/0000-0003-0193-5281 Department of Surgical and Diagnostic Sciences (DISC), University of Genoa and S. Martino Polyclinic Hospital, Genoa (GE), ItalySearch for more papers by this authorValentina Angerilli, Valentina Angerilli Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua (PD), ItalySearch for more papers by this authorEmanuele Damiano Urso, Emanuele Damiano Urso Chirurgia Generale 3^, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, ItalySearch for more papers by this authorFrancesca Bergamo, Francesca Bergamo Medical Oncology Unit 1, Clinical and Experimental Oncology Department, Veneto Institute of Oncology, IOV-IRCCS, Padua (PD), ItalySearch for more papers by this authorMatteo Fassan, Matteo Fassan Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua (PD), Italy Veneto Institute of Oncology, IOV-IRCCS, Padua (PD), ItalySearch for more papers by this author First published: 17 May 2023 https://doi.org/10.1111/his.14944Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. References 1Fassan M, Scarpa A, Remo A et al. Current prognostic and predictive biomarkers for gastrointestinal tumors in clinical practice. Pathologica 2020; 112; 248– 259. 2Chou A, Fraser T, Ahadi M et al. NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas-a study of 4569 cases. Mod. Pathol. 2020; 33; 924– 932. 3Kim JH, Hong JH, Choi Y et al. NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions. J Pathol 2021; 255; 399– 411. 4Wang H, Li ZW, Ou Q et al. NTRK fusion positive colorectal cancer is a unique subset of CRC with high TMB and microsatellite instability. Cancer Med 2022; 11; 2541– 2549. 5Ukkola I, Nummela P, Kero M et al. Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers. Virchows Arch 2022; 480; 807– 817. 6Zhang Z, Pang J, Chen L et al. Pan-tropomyosin receptor kinase immunohistochemistry is a feasible routine screening strategy for NTRK fusions in mismatch repair-deficient colorectal carcinomas. Hum. Pathol. 2022; 129; 21– 31. Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation