Novel (E)-3-(1-substituted-1H-indazol-5-yl)-N-hydroxypropenamides as histone deacetylase inhibitors: design, synthesis and structure–activity relationships

Sang Minh Doan,Eun Jae Park,Duong Tien Anh,Do Thi Mai Dung,Le Quang-Bao,Hai Pham-The,Dao Thi Kim Oanh,Truong Thanh Tung,Ik Ho Na,Joo Hee Kwon,Jong Soon Kang,Sang‐Bae Han,Dinh Thi Thanh Hai,Nguyen Hai Nam

New Journal of Chemistry（2023）

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摘要

Two series of N -hydroxybenzamides showed excellent HDAC inhibition and cytotoxicity against three human cancer cell lines, including SW620, PC3, and MDA-MB-231.

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histone deacetylase inhibitors,synthesis

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