Somatic mutation rates scale with lifespan across mammals

Alex Cagan,Adrian Baez‐Ortega,Natalia Brzozowska,Federico Abascal,Tim Coorens, Shang‐keng Ma, Lawson ARJ, Harvey LMR,Shriram G. Bhosle, David R. Jones,A. A. M. del Re, Butler Tm,Yvette Hooks,Kathryn G. Roberts,Elizabeth Anderson, Sonja Lunn,Edmund Flach, Stephen Spiro,Inez Januszczak,Ethan Wrigglesworth,Heather Jenkins,Tad Dallas,Nic Masters, Perkins MW,Robert Deaville, Maralyn Druce,Ruzhica Bogeska, Milsom MD,Björn Neumann,Frank Gorman,Fernando Constantino‐Casas,Laura Peachey,Diana Bochyńska, Smith ESJ,Moritz Gerstung,Campbell PJ, Murchison EP,Stratton Mr,Iñigo Martincorena

Yearbook of pediatric endocrinology（2023）

引用 134|浏览25

暂无评分

摘要

In Brief: To document variations in rates of somatic mutations, the authors performed whole-genome sequencing of DNA from cells of intestinal crypts across 16 diverse mammalian species, spanning huge 40 000-fold variations in body mass and 30-fold variations in lifespan. The somatic mutation rates per year varied greatly across species and showed a much stronger inverse relationship with species lifespan than with species body mass.

查看译文

关键词

somatic mutation rates,lifespan

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要