A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice
NATIONAL SCIENCE REVIEW(2023)
摘要
Neuroimmune connections have been revealed to play a central role in neurodegenerative diseases (NDs). However, the mechanisms that link the central nervous system (CNS) and peripheral immune cells are still mostly unknown. We recently found that specific ablation of the Arf1 gene in hindbrain and spinal cord neurons promoted NDs through activating the NLRP3 inflammasome in microglia via peroxided lipids and adenosine triphosphate (ATP) releasing. Here, we demonstrate that IL-1 beta with elevated chemokines in the neuronal Arf1-ablated mouse hindbrain and spinal cord recruited and activated gamma delta T cells in meninges. The activated gamma delta T cells then secreted IFN-gamma that entered into parenchyma to activate the microglia-A1 astrocyte-C3-neuronal C3aR neurotoxic pathway. Remarkably, the neurodegenerative phenotypes of the neuronal Arf1-ablated mice were strongly ameliorated by IFN-gamma or C3 knockout. Finally, we show that the Arf1-reduction-induced neuroimmune-IFN-gamma-gliosis pathway exists in human NDs, particularly in amyotrophic lateral sclerosis and multiple sclerosis. Together, our results uncover a previously unknown mechanism that links the CNS and peripheral immune cells to promote neurodegeneration.
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关键词
neurodegenerative diseases,disease-associated microglia,gamma delta T cells,reactive astrocyte,IFN-gamma,C3
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