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Soluble B7-H3 in Colorectal Cancer

O. V. Kovaleva, A. N. Gratchev,N. Yu. Sokolov, V. V. Maslennikov, Yu.B. Kuzmin, E. S. Gershtein, A. A. Alferov, Z. Z. Mamedli, I. S. Stilidi, N. E. Kushlinskii

Bulletin of Experimental Biology and Medicine（2023）

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Abstract
We present the results of comparative ELISA of the concentration of soluble form of immunity checkpoint B7-H3 (sB7-H3) in the serum of patients with colorectal cancer (CRC) at different stages before treatment and healthy control donors. The analysis revealed a statistically significant difference between the median levels of sB7-H3 in the blood serum of CRC patients (19.66 ng/ml) and healthy donors (16.76 ng/ml) (p=0.0025). ROC analysis showed 62.9
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colorectal cancer,soluble
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