Study of platelet-derived growth factor receptor beta in bone marrow biopsy samples of patients with multiple myeloma

Background Multiple myeloma (MM) is a malignant neoplastic disease manifested by uncontrolled proliferation of plasma cells in the bone marrow, production of monoclonal immunoglobulins, and associated organ dysfunction. Platelet-derived growth factor receptor beta (PDGFR-β) has demonstrated an important role in angiogenesis and neoplastic diseases. Aim The aim of this work was to calculate the expression of PDGFR-β in bone marrow trephine biopsy samples of newly diagnosed patients with MM and its clinical significance. Patients and methods A total of 20 newly diagnosed patients with MM were enrolled in this study. The expression of PDGFR-β on plasma cells in bone marrow trephine biopsy samples was assessed by immunohistochemical staining. Results Our results showed a statistically significant increase in lactate dehydrogenase, beta 2 microglobulin, and clonal plasma cell percentage in bone marrow of patients with high PDGFR-β expression in comparison with patients with negative and intermediate PDGFR-β expression and statistical significant decrease in albumin and prognostic-free survival in patients with high PDGFR-β expression in comparison with patients with negative and intermediate PDGFR-β expression. Conclusion Patients with MM with high PDGFR-β expression had unfavorable prognosis in terms of prognostic-free survival and advanced disease stage compared with intermediate and low PDGFR-β expressions.