A Novel Magnetically Recoverable Catalyst for Preparation of Polyhydroquinolines: Fe₃O₄@DABA-PA-CuBr₂ Nanocomposite Catalyzed Multicomponent Reactions under Water

The synthesis of heterocyclic compounds is very interesting topic among synthetic chemists because these compounds are widely used in various fields, especially in medicinal chemistry. In this category, polyhydroquinoline derivatives have attracted profound attention among synthetic chemists because these derivatives are used as anti-virus, anti-tumor, anti-fungal, anti-bacterial and anti-cancer agents. Therefore, the design of novel, ecofriendly and efficient catalytic systems for their preparation is an important challenge in organic synthesis. In this article, we designed and constructed a novel and environmentally benign solid catalyst was fabricated by grafting tetra dentate picolinic acid-Cu complex active species onto the 3,4-Diaminobenzoic acid functionalized Fe3O4 support [Fe3O4@DABA-PA-CuBr2] for the synthesis of polyhydroquinolines under ecofriendly conditions. The results of these experiments clearly show that this catalytic system is very efficient in the synthesis of polyhydroquinolines because the desired products were synthesized with high to excellent yields. Finally, the reusability investigation indicated that the synthesized catalyst possessed sufficient recyclability of up to eight times with negligible drop in the catalytic activity.