Abstract 1380: Blocking autophagy ameliorates the severity of ConA induced autoimmune hepatitis in mice

Abstract Autoimmune hepatitis (AIH) recognized as a typical inflammation-triggered liver disease, which usually begins as acute hepatitis and ultimately develops to fibrosis, liver damage, loss of function of liver. It largely leads to the disease-related mortality and morbidity. However, the mechanism AIH remains unclear and the novel therapeutic reagents and methodology are urgently needed. In the present study, we established the ConA induced autoimmune hepatitis model in-house and evaluate autophagy and other immune signaling pathway on the participation of AIH. Our results bring the direction for the future direction of novel therapeutic reagents discovery. Citation Format: Juan Wang, Cheng Qian, Chuanzhi Yangmeng, Li Fang, Ruiqing Yan. Blocking autophagy ameliorates the severity of ConA induced autoimmune hepatitis in mice [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1380.