Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models: Applications

The concept of finite absorption time is applied to a detailed discussion of generated models in bioavailability and bioequivalence. Considering detailed expressions for full and partial areas under the curve (AUCs), interesting conclusions are arrived at. Old digoxin pharmacokinetic data are reanalyzed under this prism. Physiologically based pharmacokinetic modeling and pharmacometrics are contrasted with the models derived from the Finite Absorption Time (FAT) concept and complicated concentration profiles successfully fit with these models.