Baseline urine albumin to creatinine ratio was associated with decline of eGFR in patients with newly diagnosed type 2 diabetes: An observational 5-year cohort study

This study aims to investigate the association between baseline albuminuria and progression of diabetic kidney disease in newly diagnosed type 2 diabetes.A retrospective cohort study was conducted among 604 patients aged≥18 years old who were newly diagnosed with type 2 DM between January 2014 and 31 December 2017 at outpatient clinic for newly diagnosed type 2 diabetes in a tertiary hospital in China. The incidence of albuminuria was determined and the associations between albuminuria at baseline and progression of diabetic kidney disease (DKD) estimated by eGFR slope were evaluated using binary logistic regression analysis.At diagnosis of type 2 DM, 18.8% of patients had albuminuria, with 17.4% having microalbuminuria and the other 1.4% having macroalbuminuria. During the 5-year follow-up peroid, patients with albuminuria at baseline experienced a more rapid decline of eGFR over time than patients with normoalbuminuria at baseline (-2.6 vs. -1.5ml/min/1.73m2 per year, p = 0.01). The albuminuria at baseline is independently associated with progression of DKD.The prevalence of albuminuria is 18.8% in patients with newly diagnosed type 2 diabetes and the occurrence of albuminuria can predict steeper annual decline in kidney function.