IN VITRO ANTIOXIDANT, ANTI-INFLAMMATORY ACTIVITIES AND ACETYLCHOLINESTERASE INHIBITION PROPERTIES OF SELECTED PLANT EXTRACTS

Plant extracts remain an infinite source of bioactive chemicals and an inexhaustible resource for discovering new drugs of natural origin. Thus, in this study, we focused on analyzing 29 ethanolic extracts (E1-E29) from selected flora of Poland to assess their antioxidant, anti-inflammatory and acetylcholinesterase inhibitory properties in relation to the chemical profiles of phenolic compounds. The results show that the investigated samples differed in terms of their chemical compositions and biological activities. The extract from Cirsium palustre leaves (E13) possessed the highest phenolic and flavonoid content as well as antiradical activity in the DPPH (2,2-diphenyl-1-picrylhydrazyl) test (415.28 +/- 2.22 mu M of Trolox equivalent). On the other hand, the most potent anti-inflammatory agents (at 125 mu g/mL) were extracts from Odontites vulgaris herbs (E24), with a COX-2 (cyclooxygenase-2) inhibition percentage of 74.54 +/- 0.77, and Erigeron acris flower heads (E22), with a 15-sLOX (soybean 15-lipooxygenase) inhibition percentage of 42.45 +/- 3.32. All extracts exhibited moderate acetylcholinesterase inhibitory activity. Moreover, to the best of our knowledge, the present study is the first to report phytochemical and pharmacological analyses of extracts from Anthericum ramosum and Lysimachia europaea.