Establishing Stereochemical Comparability in Phosphorothioate Oligonucleotides with Nuclease P1 Digestion Coupled with LCMS Analysis

Zifan Li,Fei Tong,Li Xiao,Nicholas R. Larson,Xuan Zhou,Yueheng Zhang,Jonas P. Immel‐Brown,George M. Bou-Assaf

Analyst（2023）

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摘要

NP1 digestion coupled with UHPLC-HRMS can provide valuable information on stereochemical comparability between phosphorothioate oligonucleotides by examining digestion fragments.

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关键词

phosphorothioate oligonucleotides,nuclease p1 digestion,stereochemical comparability,lcms analysis

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