Magnetic Resonance Elastography for Early Assessment of Response to Neoadjuvant Chemotherapy in Women with Breast Cancer

Patriek Jurrius,Omar Darwish,Daniel Fovargue, Belul Shifa, Kathleen A. Welsh, Joanna Bell, Sarah-Jane Hamilton, J. David Spence,Giacomo Annio,Renee Miller,Marian Troelstra,Ashutosh Kothari,Hisham Hamed, Georgina Bitsakou,Ali Sever, Sultana Hasso, Yasmin Giambrone,Isaac Daimiel Naranjo, Katerina Ntailiani,Keshthra Satchithananda, S. A. Willson,Sarah Pinder,Anne Rigg,David Nordsletten,Radhouène Neji,Tony Ng,Arnie Purushotham,Ralph Sinkus

openalex（2023）

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摘要

Approximately one-third of women with breast cancer undergoing neoadjuvant chemotherapy (NACT) have no discernible disease response to their treatment yet are subjected to the potential side-effects of their treatment. Currently, response to NACT is assessed by determining tumour size, contrast avidity, and lymph node involvement on MRI pre-, mid- and post-treatment. As a result, women undergo 3-4 cycles of NACT with unknown efficacy. Changes in a tumour’s biomechanics as assessed by magnetic resonance elastography (MRE) after only one cycle of NACT correlate with response to treatment, allowing for early assessment of a patient’s response to NACT.

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关键词

neoadjuvant chemotherapy,breast cancer,magnetic resonance

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