Origin of stronger binding of ionic pair (IP) inhibitor to Aβ42 than the equimolar neutral counterparts: synergy mechanism of IP in disrupting Aβ42 protofibril and inhibiting Aβ42 aggregation under two pH conditions
Physical Chemistry Chemical Physics(2023)
摘要
At pH 7.0, Aβ oligomer (AβP or AβF) acts as a galvanic battery for a dual inhibitor composed of a pair of positive and negative ions to exert an extraordinary inhibition/disaggregation effect on it by a unique synergistic mechanism.
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关键词
aβ42 protofibril,aβ42 aggregation,ionic pair,stronger binding
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