Absorbable protein stent for vasovasostomy in a rat model

Abstract PURPOSE: This study aimed to evaluate the safety and efficacy of a rapidly absorbable protein stent during microsurgical vasovasostomy. MATERIALS AND METHODS: Fifty-four rats were randomly divided into control, conventional, and stent groups. The left vas deferens was ligated in the control group and cut with double-layer suturing in the conventional group. The stent group received full-layer suturing with protein stent implantation. Patency rate, sperm quality, and reproductive hormones were evaluated up to 8 weeks. Pathological changes were determined by assessment. RESULTS: Patency rates were similar for the stent and conventional groups (8th week) ( p > 0.05). Operation time was lower for the stent group than for the conventional group ( p < 0.05). The stent group did not differ significantly from the control or conventional groups in terms of effects on sperm quantity, motility, deformity rate, FSH level, LH level, and testosterone level ( p > 0.05). CONCLUSIONS: This study provides a foundation for future studies that may further explore the potential of protein stents in vasovasostomy and other surgical procedures.