Validation of arterial input function measurements within an extracorporeal shunt driven by mouse blood pressure for preclinical dynamic PET-MRI

Ziel/Aim The dynamic arterial radiotracer concentration (arterial input function, AIF) is difficult to determine accurately in PET of mice. We already successfully performed AIF measurements using a pump-driven extracorporeal shunt [1]. We here investigate AIF measurements using the same setup without the pump, driven by mouse blood pressure alone, as the usage of a pump may not be possible in some cases, e.g. in preclinical PET-MRI.