Transcriptome analysis of neurotransmitters and related molecules in gastric cancer tissue

Abstract Objective To investigate whether the differential expression of neurotransmitters, their receptors, and synthetases is related to the occurrence and progression of gastric cancer. Methods Gastric cancer tissue samples from 5 patients and 2 adjacent normal tissue samples were collected, the transcriptome detection of relevant molecules was performed, and the results were compared with the whole proteome data of gastric tissue from normal HPA subjects. Results HPA showed that highly expressed classic neurotransmitters and neuropeptides were not expressed or very low expressed in 5 gastric cancer tissue samples. Conclusion We believe that the main cause of gastric cancer may be the extremely low expression or no expression of neurotransmitters, neuropeptides and other genes that should be highly expressed in normal gastric tissue, resulting in out-of-control management of gastric tissue cells and then gastric cancer.