A library of cancer testis specific T cell receptors for T cell receptor gene therapy

(Molecular Therapy: Oncolytics 28, 1–14; March 2023) In the originally published version of this article, there was an error in Figure 4B. In the graph second from the top, MAGE-A1 LTQ/A1 is indicated in black, but instead this should be MAGE-A1 KVL/A2. This error has been corrected in the figure online, and the authors apologize for any confusion this may have caused.Figure 4. TCR expression and cytotoxicity of transduced primary CD8⁺ T cells against malignant cell lines (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT) A library of cancer testis specific T cell receptors for T cell receptor gene therapyde Rooij et al.Molecular Therapy - OncolyticsDecember 1, 2022In BriefIn this study, we identified, seven MAGE-specific TCRs that effectively target MAGE-A1, MAGE-A3, MAGE-A6, and MAGE-A9 in the context of HLA-A∗01:01, -A∗02:01, -A∗03:01, -B∗07:02, -B∗35:01, or -C∗07:02. These TCRs allow TCR gene therapy for an increased number of cancer patients, and development of combination TCR gene therapy. Full-Text PDF Open Access