Pharmacological inhibition of the MLL1-menin-interaction aggravates acute kidney injury induced by folic acid and ischemia/reperfusion in mice
American Journal of Physiology-renal Physiology(2023)
Abstract
Mixed lineage leukemia 1 (MLL1) is a methyltransferase that induces histone H3 lysine 4 trimethylation and exerts its functional roles by interacting with multiple subunits. In this study, we demonstrated that inhibition of MLL1 activity by MI503 or MM102 aggravated renal injury and apoptosis and suppressed renal tubular cell dedifferentiation and proliferation, suggesting that MLL1 activation during acute kidney injury acts as an intrinsic protective mechanism to mediate renal tubular cell survival and regeneration.
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Key words
folic acid,acute kidney injury,pharmacological inhibition,menin-interaction
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