Self-regulation of the posterior-frontal brain activity with real-time fMRI neurofeedback to influence conscious perception
Research Square (Research Square)(2023)
摘要
Abstract The Global Neuronal Workspace (GNW) hypothesis states that the visual percept is available to conscious awareness only if recurrent long-distance interactions among distributed brain regions activate neural circuitry extending from posterior regions to prefrontal regions above a certain excitation threshold. To directly test this hypothesis, we trained human participants to increase blood oxygenation level-dependent (BOLD) signals with real-time functional magnetic resonance imaging (rtfMRI) based neurofeedback simultaneously in four specific regions of the occipital, temporal, insular and prefrontal parts of the brain. Specifically, we hypothesized that up-regulation of the mean BOLD activity in the posterior-frontal brain regions lowers the perceptual threshold for visual stimuli, while down-regulation raises the threshold. Our results showed that participants were able to perform up-regulation of the posterior-frontal brain activity but not down-regulation. Furthermore, the up-regulation training led to a significant reduction of the visual perceptual threshold, but no significant change of perceptual threshold was observed after down-regulation training. These findings partially support the GNW hypothesis of consciousness perception, to the extent that up-regulation of the posterior-frontal regions improves conscious awareness of stimuli. However, further questions as to whether the posterior-frontal regions can be down-regulated at all, and whether down-regulation raises the perceptual threshold remain unanswered.
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关键词
fmri,conscious perception,brain,self-regulation,posterior-frontal,real-time
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