Cannabis Causes Positive, Negative, and Cognitive Symptoms and Produces Impairments in Electrophysiological Indices of Information Processing

Converging lines of pre-clinical, epidemiological, and experimental evidence support an association between cannabis, cannabinoid agonists, and psychosis (see Chapters 14 and 15). The earliest anecdotal reports on observations between the use of cannabis and subsequent psychosis have been validated by a rich literature of longitudinal studies and more recently experimental studies in humans using a wide array of subjective, cognitive, and electrophysiological outcomes relevant to psychosis. This chapter provides an overview of the subjective psychotic phenomena associated with cannabis and cannabinoids and expands on more objective cognitive and psychophysiological cannabis-related effects pertinent to psychosis.