Titelbild: Methylierung nicht‐aktivierter Alkene mit modifizierten Methyltransferasen zur Diversifizierung von Terpenoiden (Angew. Chem. 26/2023)

A methyltransferase from the green alga Chlamydomonas reinhardtii was identified and engineered for late-stage modifications of the carbon skeleton of terpenes. A variant with three changes in the amino acid sequence was able to produce methylated derivatives of linear terpenoids with high selectivity by C-methylation of an unactivated alkene. This opens new avenues for the modification of carbon scaffolds in various applications, as demonstrated by Bernhard Hauer et al. in their Communication (e202301601). Artwork: Verena Resch, Graz. Electrocatalysis Hydrogen Evolution Reaction Organoborane Fluorophores