Supplementary Figures 1-11 from Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer
openalex(2023)
摘要
S1. Experimental design
S2. Association between the variant allele frequency (VAF) of tumor mutations identified in uterine lavage with stage of the ovarian cancer (A) and preoperative CA-125 level (B)
S3. Gene distribution of the largest mutant clones identified in uterine lavage
S4. Correlations between Mutation Frequencies (MF) of genes commonly mutated in lavage DNA
S5. Comparison of Mutation Frequencies (MF) by patient group.
S6. Comparison of Mutation Frequency (MF) for individual genes in uterine lavages from patients with and without cancer
S7. Correlations between TP53 coding mutation frequency (MF) and age
S8. Distribution of driver and non-driver mutations identified in lavage DNA by gene and patient
S9. Mutation spectrum distribution of coding mutations detected in lavage DNA compared to ovarian cancer mutations reported in COSMIC
S10. Comparison of Variant Allele Frequency (VAF) of driver mutations in lavage DNA from patients with and without ovarian cancer
S11. Comparison of mutation burden (MB) of common ovarian cancer genes in lavage DNA from patients with and without ovarian cancer
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关键词
ovarian cancer,somatic mutations burden
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