Figure S2 from Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia

Lu Zhang,Tianyu Cai,Xiaoyu Lin,Xiaoli Huang,Mai H. Bui, Joshua P. Plotnik,Richard J. Bellin, Emily J. Faivre,Vinitha M. Kuruvilla,Lloyd T. Lam, Xin Lu, Zhaohui Zheng, Weiguo Feng, Paul Hessler,Tamar Uziel,Qi Zhang,Antonio Cavazos,Han Liu,Debra C. Ferguson,Gaurav Mehta,Sriram S. Shanmugavelandy, Terrance J. Magoc,Jenny Rowe,Neal Goodwin,Kathleen A. Dorritie,Michael Boyiadzis,Daniel H. Albert,Keith F. McDaniel, Warren M. Kati,Marina Konopleva,Yu Shen

openalex（2023）

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摘要

Figure S2. ABBV-744 retains strong transcription regulatory activities in AML cells and it did not alter the baseline expression of representative IFN-r or PMA responsive genes.

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关键词

bet family proteins results,acute myeloid leukemia,antitumor activity,robust antitumor activity

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