Supplemental Figures S1-6, Tables S1-7 from Impaired Self-Renewal and Increased Colitis and Dysplastic Lesions in Colonic Mucosa of AKR1B8-Deficient Mice

Supplemental Figures S1-6, Tables S1-7. Figure S1. Targeted disruption of AKR1B8 gene. Figure S2. AKR1B and AKR1C subfamily expression. Figure S3. Deficiency of proliferation and self-renewal of colonic crypt cells in AKR1B8 -/- mice. Figure S4. DSS treatment schedules. Figure S5. Spleen size and histological inflammation of AKR1B8 -/- mice treated with 2% DSS. Figure S6. Colitis-associated tumorigenesis in AKR1B8 -/- mice. Supplemental Table S1. Coverage summary of Exome sequencing. Supplemental Table S2. Variations detected throughout the mouse Exome sequencing. Supplemental Table S3. Oncogenes and tumor suppressor genes mutated in AKR1B8 -/- colitis and tumors only, but not in wild type colitis. Supplemental Table S4. Disease Activity Index. Supplemental Table S5. Histopathological Inflammation Score. Supplemental Table S6. Definition of histopathology. Supplemental Table S7. Gene specific primers.