Dil kanserli hastalarda preoperatif neoadjuvan kemoterapinin prognostik rolü

Aim: This study aimed to investigate the relationship between preoperative neoadjuvant chemotherapy (NAC) and overall survival in patients with tongue cancer who underwent glossectomy. Material and Method: The study included 35 tongue cancer patients who underwent glossectomy. Twenty patients did not receive any treatment before surgery (control group). Fifteen patients received two cycles of cisplatin-containing NAC prior to surgery. Five-year overall survival findings were compared between the groups. Results: Median pathological depth of invasion was lower in the NAC group compared to the control group (7 vs. 9 mm, p=0.037). The mortality rate was lower in the NAC group (26.7% vs. 50.0%, p=0.008). Increased depth of invasion was independently associated with increased risk of mortality, while receiving NAC was independently associated with decreased risk of mortality. The risk of mortality was 6.25-fold lower (1/0.16) in the NAC group compared to the control group (HR: 0.16, 95% CI: 0.004-0.72, p=0.017). Conclusion: Patients who underwent NAC plus surgery were associated with a higher probability of 5-year overall survival compared to patients who underwent surgery alone. These findings may be inspiring for the role of NAC prior to surgery in the prognosis of patients with tongue cancer.