Occurrence of dyslipidemia in pre-diabetic individuals: a hospital-based observational study

Background: Pre-diabetes (PD) is the precursor stage of diabetes mellitus, in which the subject's plasma glucose is higher than normal but lower than diabetes mellitus thresholds. Lipid prole disorders are signicantly associated with prediabetes and diabetes. Individuals with pre-diabetes have a high risk of progression to diabetes. Assessment of serum lipids is warranted not only for T2DM patients but also for those with prediabetes. Methods: The study was carried out in the Department of Medicine, Gauhati Medical College and Hospital, Guwahati from 1st June 2021 to 31st May 2022. After satisfying the inclusion and exclusion criteria 120 prediabetic patients were included in the study and were evaluated. Patients were categorized according to ATP III classication. In our study group, out of 120 patient Result: s, a maximum number of patients belonged to the age group of 41-50 yrs and the mean age was 48.17±10.5 years with 60.8% male and 39.2% female cases. Among the different lipids, we found hypercholesterolemia in 23.4%, hypertriglyceridemia in 62.5%, and high LDL was found in 76.7% of prediabetic subjects. In our study, we found low HDL (<40 mg/dl)levels in 64.2% of prediabetic patients. The mean value of total cholesterol was 171.1 ±50.2 , Triglyceride was 170.2 ±76.5 , HDL was 38.3 mg/dl±9.4, LDL was120.8 ±33.5 and VLDL was 30.5 ±8.6. HbA1c has a signicant positive correlation (p-value <.001) with TC, TG LDL, and VLDL and a signicant negative correlation (p-value< .001) with HDL. Pre-diabetic individuals often exhibit an Conclusion: atherogenic pattern of risk factors that include high levels of total cholesterol (CHOL), low-density lipoprotein cholesterol (LDL), triglycerides (TG), and low levels of high-density lipoprotein cholesterol (HDL), it predisposes to premature atherosclerosis causing cardiovascular and cerebrovascular complications in the long term in this individuals if not evaluated early