Radt-49. a systematic review and meta-analysis of hippocampal avoidance in whole brain radiotherapy and prophylactic cranial irradiation

Abstract RESULTS: Significantly increased survival was observed in mice treated with MHT+CRT compared to CRT alone in a therapy-resistant GBM PDX model. In vitro studies demonstrated that MHT with radiation was more cytotoxic than radiation or MHT alone. Additionally, MHT with CRT significantly increased tumoral expression of biomarkers for DNA double-strand breaks (g-H2AX), CD8+ T cell recruitment (CD8), and inflammation (P-selectin) compared to CRT alone, suggesting MHT-mediated radio-sensitization and immune cell recruitment to the tumor. MIONP heating was confirmed in the test tube (93.3 oC) and intracranially (50.7 oC) within minutes of AMF exposure, and localization of MIONPs to the delivery site was verified with imaging.