Generation of Non-Alloreactive Antiviral Central Memory CD8 Human Veto T Cells for Cell Therapy

Esther Bachar-Lustig,Assaf Lask,Yaki Eidelstein,Noga Or-Geva,Rotem Gidron-Budovsky,Bar Nathansohn-Levy,Matthias Eyrich,Wei-Hsin Liu, Giang Dang,Karla Castro Miranda,Alejandro Ramirez,Indreshpal Kaur,Katayoun Rezvani,Elizabeth Shpall,Richard E. Champlin,Arnon Nagler,Avichai Shimoni,Sivan Barnees-Kagan,Yair Reisner

Transplantation and Cellular Therapy（2024）

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摘要

•Here we describe 2 alternative methodologies for generating antiviral CD8 veto cells for a first in-human clinical trial.•A >3-log depletion of alloreactivity confers a low risk of GVHD.•Expanded veto cells exhibit robust antiviral activity and are not exhausted.

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关键词

cells,cells,cd8,non-alloreactive,anti-viral

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