Diastolic Dysfunction and Health Status Outcomes After Transcatheter Aortic Valve Replacement

Graphical Abstract: Association between change in LVDD and change in health status. (a) The change in LVDD severity from baseline to 1 year following TAVR. The thickness of the arrows reflects the proportion of the total number of patients in the study (N = 1100). Counts and percentages above the arrows reflect the proportion of patients within each baseline LVDD grade that improved, worsened, or remained unchanged after TAVR. Majority of patients were either improved or unchanged. (b) The least squares mean difference in change in health status in patients with improved LVDD or worsened LVDD vs. unchanged LVDD. Change in LVDD severity at 1 year was independently associated with change in KCCQ-OS at 1 year. The analysis was adjusted for baseline KCCQ-OS score, age, sex, hypertension, chronic obstructive pulmonary disease, and stroke.Abbreviations: KCCQ-OS, Kansas City Cardiomyopathy Questionnaire–Overall Summary; LVDD, left ventricular diastolic dysfunction; TAVR, transcatheter aortic valve replacement.