3D Biomimetic in Vitro Model of Self-induced Cardiac Ischemia Based on the Co-culture of Cardiomyocytes Derived from hiPSC and Primary Human Cardiac Fibroblast

Laura Artigas,Sandra González‐Lana, Natividad Polo, Héctor Castro-Abril,Manuel Mazo,Ignacio Ochoa,Jesús Ciriza

Jornada de jóvenes investigadores del I3A（2023）

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摘要

Large cardiac spheroids (i.e., > 500 µm diameter) that self-induce an ischemic core were generated by co-culture of cardiomyocytes derived from induced pluripotent cells (hiPSC-CMs) and primary cardiac fibroblast (hCF). Without modification of culture conditions, spheroids’ large size allowed the recreation of a dead core, fibrotic remodelling and tissue stiffening.

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关键词

cardiomyocytes,cardiac ischemia,primary human cardiac fibroblast,vitro model,self-induced,co-culture

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