Investigation of HER2 gene amplification and protein expression in canine primary pulmonary carcinoma

Journal of Comparative Pathology(2023)

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摘要
In this paper we obtain a one velocity macroscopic description of a mixture of two viscous compressible fluids by homogenization/averaging. The paper is written in two parts that can be read independently one of the other. In the first part, we propose two numerical schemes respectively for a two-fluid immiscible system, (i.e. two fluids separated by sharp interfaces) and for a bifluid mixture system (diffuse interface description via volume fractions). We present various simulations that suggest that the two systems of equations describe the same mixture at different scales and, as a consequence, that averaged velocity, density and pressure of the first model match with the respective velocity, density and pressure of the second model. In a second part, we show how to mathematically formalize the previous assertion via kinetic equations verified by the Young measures associated to oscillatory solutions of the model describing the finer scale.
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关键词
her2 gene amplification,primary pulmonary carcinoma,protein expression
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