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Subclinical Myocardial Leukocyte Infiltration after COVID-19 Vaccination in Heart-Transplant Recipients

Daniel Oehler,Fabian Voß,Daniel Scheiber,Schultheiss Hp,Malte Kelm,A. Lichtenberg,Udo Boeken,R Westenfeld

Thoracic and Cardiovascular Surgeon（2023）

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Abstract
Background: mRNA-based COVID-19 vaccines have been reported to rarely cause myocarditis. Although myocardial biopsy is considered gold standard in the diagnosis of myocarditis, no standardized study following COVID-19 vaccination in humans was performed so far. Since heart transplant (HTX) recipients frequently undergo routine myocardial biopsy, we here aimed to investigate effects of COVID-19 vaccination by analyzing myocardial inflammation by state-of-the-art quantitative immunohistochemistry.
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Key words
subclinical myocardial leukocyte infiltration,heart-transplant
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