Synthesis, characterization, and biological activity of new metal complexes derived from 1,2,4-triazole Schiff base ligand

Bionatura (Ibarra - Impresa)(2023)

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摘要
The present study involves the synthesis of a new Schiff base ligand (L) and its complexes(C1-C5) with Co (II), Ni (II), Cu (II), Pd (II), and Pt (IV). The ligand was synthesized by the condensation reaction of 4-Amino-5-(3,4,5-trimethoxy phenyl)-4H-1,2,4-triazole-3-thione (1) with 2-hydroxy-1-naphthaldehyde (2). The structures of the new ligand and its complexes were confirmed by FT-IR, UVvisible, 1H NMR, 13C NMR, mass spectrometry, microelement analysis (CHNS), atomic absorption flame (AAF) spectrophotometry, conductivity, and magnetic susceptibility analysis. The antibacterial activity of the ligands (L) and their complexes (C1–C5) was examined in vitro against the gram-positive and gram-negative bacteria Staphylococcus aureus and Escherichia coli, with the (MIC) values being compared to two common antibiotics. Furthermore, Aspergillus flavus and Penicillium spp. were used as test subjects for the novel compounds' antifungal properties. Keywords: Schiff base, triazole, metal complexes, antibacterial, antifungal.
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new metal complexes,metal complexes,synthesis
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