Side effects of antipsychotic agents

Antipsychotic agents have been categorized into two classes, typical and atypical. They are also known as first (typical) and second (atypical) generation antipsychotics. This chapter discusses the rare side effects of the first and the second generation antipsychotics published during January to December 2022. Clozapine, one of the second generation antipsychotics is the most effective and considers a gold standard to manage the symptoms associated with schizophrenia. This chapter includes some of the rare adverse effects associated with clozapine. Further the interaction of Pfizer-BioNTech COVID 19 mRNA vaccine with clozapine is also included. Reports on the benefit of benzodiazepines in treating olanzapine-induced restless leg syndrome is also included in this chapter. Practicing clinicians in this specialty should be aware of these rare adverse effects of antipsychotics when prescribing these medications.