Synthesis of Propargylamine and Indolazine Derivatives via Three‐Component Reaction Catalyzed by CuO_x/CeO₂ Materials

Abstract In this paper, nanorod CeO 2 supports were prepared by hydrothermal method using Ce(NO 3 ) 3 ⋅ 6H 2 O as raw material. CuO x /CeO 2 ‐r materials were prepared by calcination using Cu salt‐loaded CeO 2 ‐r supports as raw materials. The three‐component coupling reaction of phenylacetylene, amine and aldehyde was successfully catalyzed by CuO x /CeO 2 ‐r material as a non‐homogeneous catalyst, which showed good catalytic activity. Furthermore, a series of indolizine derivatives can be obtained in higher isolated yields by replacing benzaldehyde with pyridinecarbaldehyde and catalyzing the three‐component synthesis with the same CuO x /CeO 2 ‐r material. The synthesis mechanisms of propargylamine and indolizine were discussed. It is worth noting that the CuO x /CeO 2 ‐r material system is provided for two three‐component reactions, and has the advantages of less catalyst dosage, short reaction time, simple post‐treatment, and a wide range of substrates.