Polygenic genetic variation affecting antibody formation underlies hypertensive renal injury in the stroke-prone spontaneously hypertensive rat
American Journal of Physiology-renal Physiology(2023)
摘要
Here, we used a polygenic animal model of hypertensive renal disease to show that genetic variation affecting antibody formation underlies hypertensive renal disease. We proved the genetic thesis by generating an immunoglobulin knockout in the susceptible animal model.
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关键词
hypertensive renal injury,polygenic genetic variation,stroke-prone
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