Innenrücktitelbild: Mechanochemistry‐Amended Barbier Reaction as an Expedient Alternative to Grignard Synthesis (Angew. Chem. 39/2023)

Mechanochemistry makes the next move in advancing organometallic synthesis. In their Research Article (e202305775), Riina Aav, Dzmitry G. Kananovich et al. report a mechanochemical adaptation of the Mg-mediated Barbier reaction, which overcomes the limitations of the classic solvent-based approach. Mechanochemical activation enables the rapid generation of Grignard reagents in situ, making the process resistant to air and allowing solid Brønsted acids to be used as additives to improve yields.