#4913 ANALYSIS OF THE LIPID PROFILE IN THE RENAL PATIENT AND SUB-ANALYSIS OF THE POPULATION WITH POLYCYSTIC KIDNEY DISEASE

Abstract Background and Aims Dyslipidemia is frequent in patients with chronic kidney disease (CKD), it constitutes a factor of progression of both cardiovascular risk (CVR) and CKD itself. It has its own characteristics, which are modified with the ERC stadium. The subgroup of patients with Polycystic Kidney Disease (PKD) presents its own characteristics. The aim of the study was to analyze the lipid profile in the renal population and the differences in the PKD group. Method Retrospective observational study, includes population under follow-up in nephrology consultations in a health area, during 2018–2021. We analyzed lipid profile, renal function and whether they received statins. IBM SPSS Statistics V24 was used. Results 3301 prevalent patients with kidney disease were collected, excluding those on renal replacement therapy (RRT), with glomerular filtration rate (GFR), glomerular filtration rate (GFR) <10ml/min/1.73m² and proteinuria greater than 1.5g. Of these, 112 (3.4%) patients had PKD. 51% of the total CKD patients were under treatment with statins. The average number of Total Cholesterol (TC) was 170.4+/-43mg/dl, LDL 92.3+/-37mg/dl, HDL 50.3+/-15mg/dl and triglycerides (TG) 147.3+/-92mg/dl. In 37% of CKD patients, LDL was >100mg/dl and only 35% had LDL<75mg/dl. In the CKD group with a GFR <60ml/min/1.73m² (N = 2337; 71%), there was a high prevalence of patients with LDL values >100mg/dl (N = 784; 33.5%). In the case of GFR <30ml/min/1.73m² (N = 981; 29.7%), the presence of LDL>100mg/dl 30% (N = 297) was also frequent. In the subanalysis of patients with PKD, the mean TC was 182+/-40mg/dl, LDL 101.2+/-33mg/dl, HDL 56.4+/-17mg/dl, and TG 123.7+/-59mg/dl. 76% of the PKD had GFR <60ml/min/1.73m² (N = 73), of which 43% presented LDL>100mg/dl (N = 32). In PKD patients with GFR > 60ml/min/1.73m² (N = 39), half (N = 22; 56.4%) also had LDL >100mg/dl. In addition, 51% were taking a statin, despite this they had a mean TC 183mg/dl+/-46, LDL 102.7+/-39, HDL 53+/-15, and TG 142+/-69mg/dl. Conclusion The presence of elevated LDL was frequent in CKD, especially in the group with GFR < 60ml/min/1.73m² without statin and in a quarter of patients with the same GFR with statin. It is notable in the PKD group, probably due to less awareness of strict CVR control.