A Comprehensive Integrated Analysis of DDX3X Expression, Prognostic Value and Potential Implications for Pan-Cancer Immunity

Xi Pang, Jingmin Ji, Xinyu Cai,Shanming Ruan, Han Seung Jin

Research Square (Research Square)(2023)

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摘要
Abstract Background: DEAD-box RNA Helicases (DDX3X) is a category of protein that imitate tumourigenesis, invasion, and immune escape by competing in RNA absorption and binding proteins, but allure system debris is expected purified. Methods: In our research, Cancer Genome Atlas and the Genotype-Tissue Expression Database were discovered to decide the changed verbalization of DDX3X in pan-carcinoma growth, and TIMER (Tumor Immune Estimation Resource) was used to discover the verbalization of DDX3X and the level of invulnerable combination. It’s rooted that DDX3X verbalization was well compared accompanying an assortment of diseased invulnerable genes, invulnerable container combination and cut, carcinoma mutational load, and DNA microsatellite inconstancy. DDX3X keep thus be secondhand as a prognostically appropriate immunotherapeutic goal for malignancy forecast.
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关键词
ddx3x expression,immunity,pan-cancer
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