Gc-Ms Analysis And In Vitro Antibacterial Activity Of The Essential Oil Of Cinnamodendron dinisii Schwacke (Canellaceae) Against Multirresistant Strains

Medicinal plants are used as cheaper alternatives for the treatment of certain pathologies. Due to the great Brazilian biodiversity, many plants do not have in-depth studies such as Cinnamodendron dinisii Schwacke (pepper or pau-pra-tudo), which is native to the south and southeast. The aim of this study was to evaluate the antibacterial activity of Cinnamodendron dinisii Schwacke essential oil (OECd) against multiresistant strains: Escherichia coli 06 (EC 06) and Staphylococcus aureus (SA 10). Ampicillin, Norfloxacin and Gentamicin were diluted in distilled water and used for the modulatory test. The tests followed the methodology of microdilution in broth to obtain the Minimum Inhibitory Concentration (MIC). The MIC/8 of the products was used in the resistance reversal test. In terms of direct activity, OECd showed the best result against S .aureus with a MIC of 512µg/mL. For bacterial resistance reversal tests, OECd showed better synergistic interactions with the antibiotics ampicillin and gentamicin, both against E.coli strains. The results demonstrate that OECd has antibacterial action when tested alone or in combination with antibiotics against multidrug-resistant strains.