Ps-c12-6: association between defecation status and blood pressure variability

Background: Blood pressure variability (BPV) is an independent predictor for cardiovascular disease. Defecation status has also been linked to the risk of developing cardiovascular disease. Aim: To investigate the association between BPV and defecation status Methods: A total of 184 participants who were able to measure their home blood pressure at least 8 days per month at both baseline and 1 year later were included in the study. All participants measured home blood pressure (BP) using HEM-9700T (OMRON Healthcare). Day-to-day variability of systolic BP were evaluated by coefficient of variation (CV) of home systolic BP during one month. Data on defecation status was obtained by questionnaire survey and good defecation status was defined as having a bowel movement every day. Results: In multivariate regression analysis with the change of CV from baseline to 1 year later as the objective variable and age, gender, Good defecation status, taking medication including antihypertensive drugs, laxatives, intestinal preparations, and CV at baseline as independent variables, good defecation status is independently negatively associated with the elevated CV (β;: -0.669, P = 0.0019). Conclusion: Good defecation status is shown to be significantly associated with decreased BPV.