Ps-p16-1: influence of age and sex on the relationship between map and central pulse pressure during young adulthood

The present study evaluates the interplay between age and sex on the relationship between MAP and brachial and central PP in young to middle-aged hypertensive patients. This is a cross-sectional study of hypertensive patients referred for radial pulse wave evaluation (Sphygmocor device). A total of 312 patients (69% under antihypertensive treatment), mean age 35 ± 9 years (16–49 years) and 134 ± 14 /82 ± 10 mmHg, with operator index > 70% were included. As shown in the figure, increasing age was associated with a progressive dissociation of central PP between subgroups of MAP below and above the mean (100 mmHg), reaching statistical significance in women only (P = 0.01 for the interaction between age and MAP). Higher MAP significantly boosted the age-related increase in AP (p = 0.01 in men and 0.049 in women for the interaction between age and MAP). The strength of the correlation between MAP and central PP increased with age more steeply in women than in men (see the table). Multiple regression analyses including the agexMAP interaction term confirmed the interaction between age and MAP on central PP in both sexes. In conclusion, the association between distending pressure and PP increases in strength from early adulthood to midlife. Women are more vulnerable to the effect of MAP on central pulsatility. JOURNAL/jhype/04.03/00004872-202301001-01311/figure1/v/2023-10-20T023332Z/r/image-jpeg