Ps-c29-11: impact of underweight, overweight, and obesity on endothelial function: fmd-japan registry

Background: The association of body weight with cardiovascular outcomes is still controversial. The aim of this study was to evaluate the association between body mass index (BMI) and endothelial function. Methods: We evaluated endothelial function by measuring flow-mediated vasodilation (FMD) in 7682 men. All participants were divided into four groups by BMI: underweight (< 18.5 kg/m2), normal weight (18.5 to 24.9 kg/m2), overweight (25.0 to 29.9 kg/m2), and obesity (≧ 30.0 kg/m2). We evaluated the cross-sectional associations between endothelial function and BMI. Results: After adjustment for various confounders, overweight (OR: 1.30, 95% CI: 1.14–1.47; P < 0.001) and obesity (OR: 1.40, 95% CI: 1.09–1.80; P = 0.009) were associated with endothelial dysfunction. In 5571 younger adults (< 60 years), overweight (OR: 1.34, 95% CI: 1.16–1.55; P < 0.001) and obesity (OR: 1.37, 95% CI: 1.04–1.81; P = 0.03) were associated with endothelial dysfunction, and underweight (OR: 0.56, 95% CI: 0.35–0.89; P = 0.01) was associated with a reduced risk of endothelial dysfunction. In 2111 older adults (≧ 60 years), underweight (OR: 2.16, 95% CI: 1.22–3.80; P = 0.008) was associated with endothelial dysfunction, and overweight and obesity were not associated with endothelial dysfunction. Conclusions: Endothelial function was impaired in the overweight and obesity groups compared with that in the normal weight group. The risk for endothelial dysfunction was higher in obese younger adults than in obese older adults. The association of BMI with endothelial function may be different in young and elderly men.