Front Cover Picture: Mechanochemical Ni‐Catalysed Arylation of ortho‐Hydroxyarylenaminones: Synthesis of Isoflavones (Adv. Synth. Catal. 20/2022)

The front cover picture is a metaphor of mechanochemistry. A pair of robotic arms is playing dominoes with the mechanism of Ni-catalyzed domino-cyclisation-arylation of o-hydroxyarylenaminones, elucidated by the experimental and computational investigations in our group. Meanwhile, another set of mechanical contraptions working at 30 Hz is about to ground the domino tiles as they fall to obtain isoflavones under mechanochemical conditions. This is the first example where the mechanic energy is used in the synthesis of isoflavones following a domino cyclisation. Details can be found in the Research Article by Iaroshenko and co-workers (S. Mkrtchyan, M. Jakubczyk, S. Lanka, M. Yar, T. Mahmood, K. Ayub, M. Sillanpää, C. M. Thomas, V. O. Iaroshenko, Adv. Synth. Catal. 2022, 364, 3512–3521; DOI: 10.1002/adsc.202200645).