Comparison of the clinical manifestations and chest CT findings of pulmonary cryptococcosis in immunocompetent and immunocompromised patients: A systematic review and meta-analysis

Abstract Objective The purpose of our study was to perform a meta-analysis and systematic review to compare differences in clinical manifestations and radiographic findings between immunocompetent and immunocompromised pulmonary cryptococcosis (PC) patients. Methods An extensive search for relevant studies was performed using the PubMed, EMBASE, Cochrane Library, and Web of Sciences databases from inception to September 30, 2021. We included studies that compared the clinical manifestations and chest computed tomography (CT) findings between immunocompetent and immunocompromised PC patients. Study bias and quality assessment were performed using the Newcastle–Ottawa Scale (NOS). Results Nine studies involving 248 immunocompromised and 276 immunocompetent PC patients were included in our analysis. The NOS score of each eligible study was above 5, indicating moderate bias. The proportion of elderly patients (>=60 years old) in the immunosuppressed group was significantly higher than that in the immunocompetent group (OR=2.90, 95% CI (1.31-6.43), Z=2.63, p=0.01). Fever (OR= 7.10, 95% CI (3.84-13.12), Z= 6.25, p<0.000) and headache (OR= 6.92, 95% CI (2.95-16.26), Z=4.44, p<0.000) were more common in immunosuppressed patients. According to thin-section CT findings, lesions were more frequently distributed in the upper lobe (OR= 1.90, 95% CI (1.07-3.37), Z= 2.2, p=0.028) in immunocompromised individuals. The proportions of patients with cavity sign (OR= 5.11, 95% CI (2.96-8.83), Z= 5.86, p=0.00), ground-glass attenuation (OR= 5.27, 95% CI (1.60-17.35), Z= 2.73, p=0.01), and mediastinal lymph node enlargement (OR= 2.41, 95% CI (1.12-5.20), Z= 2.24, p=0.03) were significantly higher in immunocompromised patients. Conclusion No significant differences in nonspecific respiratory symptoms were found between immunocompromised and immunocompetent PC patients. Nevertheless, fever and headache were more common in immunocompromised patients. Among the CT findings, cavity, ground-glass attenuation, and mediastinal lymph node enlargement were more common in immunocompromised individuals.