A measure of the trigeminal blink reflex to parametric variation of mechanical stimulation

Abstract The primary goal of this study was to develop a parametric model that relates variation in trigeminal stimulation to properties of the blink response. We measured blink responses in 17 healthy, adult participants to air puffs delivered to the cornea and lateral canthus at five different, log-spaced intensities (3.5 - 60 PSI). Lid position over time was decomposed into amplitude, velocity, and shape components. We found that blink amplitude was lawfully related to log stimulus intensity, with the relationship well described by a Weibull cumulative density function. The parameters of the Weibull fit correspond to the slope of the function and the stimulus intensity required to produce half of a maximal blink response (the half-response threshold). There was a reliable decrease in half-response threshold for the contralateral as compared to ipsilateral blink response. This decrease was consistent across participants despite substantial individual differences in the half-response threshold and slope parameters of the overall sensitivity function, suggesting that the laterality effect arises in the neural circuit subsequent to individual differences in sensitivity. Overall, we find that graded mechanical stimulation of the trigeminal afferents elicits a graded response that is well described by a simple parametric model. We discuss the application of parametric measurements of the blink response to the detection of group differences in trigeminal sensitivity. Impact statement There has been limited study of how variation in stimulus intensity influences the blink response. We describe how variation in the intensity of an air-puff stimulus relates to the amplitude of the blink response using a two-parameter model. The parameters of this model allow us to measure individual differences in the sensitivity of the trigeminal blink response, which may be used in future studies to identify population differences in this system.