Inside Cover: Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering (Angew. Chem. Int. Ed. 2/2023)

Darobactins bind to the novel antibiotic target BamA in the outer membrane BAM-complex of Gram-negative pathogens. The renewal of the outer membrane proteins is prevented and bacteria are lysed. The new derivative D22 was created through cryo-EM structure- and activity-guided biosynthetic engineering as described by Thomas C. Marlovits, Jennifer Herrmann, Rolf Müller, and co-workers in their Research Article (e202214094), and showed superior potency against multidrug-resistant clinical isolates, for which most antibiotics on the market are no longer effective.