Target search on DNA -- effect of coiling
arxiv(2023)
摘要
Some proteins can find their targets on DNA faster than by pure diffusion in
the 3-dimensional cytoplasm, through the process of facilitated diffusion: They
can loosely bind to DNA and temporarily slide along it, thus being guided by
the DNA molecule itself to the target. This chapter examines this process in
mathematical detail with a focus on including the effect of DNA coiling on the
search process.
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